cron is a time-based job scheduler. It means you can run specific operations at a certain time.
dunst is a lightweight and customizable notification daemon. You can post notifications from the command line using the tool dunstify.
echo $DISPLAY
echo $DBUS_SESSION_BUS_ADDRESS
*/20 * * * * DISPLAY=:0 DBUS_SESSION_BUS_ADDRESS=unix:path=/run/user/1000/bus dunstify -u critical "Time to take a break" "Get up, strech your legs and rest your eyes"
This will create a popup notification with the given title and description and which will stay active until you click on it.